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2010•Medical Journal of Chinese People's HealthRequires access

Comparative study between Risperidone and Perphenazine in the treatment of female patients with schizophrenia

Sujuan Zheng

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Abstract

Objective:To detect the clinical efficacy and side effects of Risperidone and Perphenazine in the treatment of female schizophrenic patients. Methods:68 female schizophrenic patients have been divided into Risperidone group and Perphenazine group randomly to treat for 8 weeks. Positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and side effects respectively.Results:There were no significant difference between two groups (P0.05).However,Risperidone took effect more quickly But,significant difference were found between two groups in the reduction rate of scale about negative symptoms (P0.05).Patients in Risperidone group reported much fewer side effects than those in Perphenazine group,especially in the items of skathisia,tachycardua,tremor,and blur sight on TESS (P0.05).Conclusions:Risperidone is an effective antipsyshotic drug with fewer side effects.

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What this paper is about

Objective:To detect the clinical efficacy and side effects of Risperidone and Perphenazine in the treatment of female schizophrenic patients. Methods:68 female schizophrenic patients have been divided into Risperidone group and Perphenazine group randomly to treat for 8 weeks. Positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and side effects respectively.Results:There were no significant difference between two groups (P0.05).However,Risperidone took effect more quickly But,significant difference were found between two groups in the reduction rate of scale about negative symptoms (P0.05).Patients in Risperidone group reported much fewer side effects than those in Perphenazine group,especially in the items of skathisia,tachycardua,tremor,and blur sight on TESS (P0.05).Conclusions:Risperidone is an effective antipsyshotic drug with fewer side effects.

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Available abstract

Objective:To detect the clinical efficacy and side effects of Risperidone and Perphenazine in the treatment of female schizophrenic patients. Methods:68 female schizophrenic patients have been divided into Risperidone group and Perphenazine group randomly to treat for 8 weeks. Positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and side effects respectively.Results:There were no significant difference between two groups (P0.05).However,Risperidone took effect more quickly But,significant difference were found between two groups in the reduction rate of scale about negative symptoms (P0.05).Patients in Risperidone group reported much fewer side effects than those in Perphenazine group,especially in the items of skathisia,tachycardua,tremor,and blur sight on TESS (P0.05).Conclusions:Risperidone is an effective antipsyshotic drug with fewer side effects.

Key concepts: Risperidone, Perphenazine, Positive and Negative Syndrome Scale, Schizophrenia (object-oriented programming), Side effect (computer science), Medicine, Clinical efficacy, Significant difference

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