Relationship between FHIT gene and liver cancer

Fragile histidine triad(FHIT) gene lies in the chromosome 3p14.2 and belongs to HIT gene family.It is the first anti-oncogene which associates the fragility site with tumor.It can suppress tumor probably by inducing cell apoptosis.There exist hypermethylation,abnormal transcription of FHIT gene and down-regulation expression of FHIT protein in liver cancer.The alternations of FHIT gene correlate with several clinic pathological indicators such as progression,invasion,relapse rate,and survival rate of liver cancer.The alternation of FHIT gene is an early and frequent event of liver cancer,and FHIT gene as a new molecular indicator of liver cancer can monitor the prognosis of liver cancer patients.