The clinical effecacy comparison of mesalazine and SASP in the treatment of ulcerative colitis

Objective To investigate and compare the mesalazine and sulfasalazine in two groups of drugs in the treatment of mild and moderate active ulcerative colitis clinical efficacy and side effects.Methods In our hospital from 2009 December to 2011 June were mild or moderate activity of ulcerative colitis patients were randomly divided into 72 cases of mesalazine in the treatment group(observation group) and 38 cases of sulfasalazine treatment group(control group) in 34 cases,two groups were treated with continuous 56 d,observe two groups of patients clinical symptoms,various biochemical indexes,colonoscopic mucosal condition as well as the side effects.Results After 56 d treatment,the observation group the patient's condition improves significantly,the observation group in the total efficiency was significantly higher than that of the control group,the difference between the two groups is significant(P 0.05),with statistical significance.The observation group and the control group patients in the treatment of 56 d after the abdominal pain,diarrhea,stool with pus and blood,mucosal hyperemia edema,erosion,ulcer hemorrhage and vascular fuzzy situation are improved,two groups of patients showed abdominal pain and diarrhea stool frequency and reduced,endoscopic mucosal look good.Two groups of patients in the 56 d credit value of colonic mucosa were significantly decreased(P 0.05),with statistical significance.Two groups of patients,the incidence of side effects between marked difference(P 0.01),with statistical significance.The side effects during treatment to give timely symptomatic treatment,not to influence the treatment process.Conclusion Using mesalamine for mild and moderate active ulcerative colitis disease treated with satisfactory clinical curative effect,the clinical curative effect of sulfasalazine treatment group,and the application of mesalazine in the treatment of side effects were significantly reduced,is worth the clinical widely popularization and application.