Association of C(-260)T polymorphism in CD14 gene promoter with coronary heart disease in Han population of Jiangsu region

Objective To examine whether C(-260)T polymorphism in the promoter of CD14 gene is associated with coronary heart disease(CHD)in the Han population of Jiangsu region.Methods Applying polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)methods we analyzed the genotypes of 193 CHD patients,whose coronary lesions were confirmed by angiography,and 225 healthy subjects.The levels of serum lipid and sCD14 were studied by biochemical methods and ELISA method respectively.Results The frequencies of TT,CT and CC genotype of CD14 gene promoter-260 polymorphism were 41.78%,40.89%,17.33% in healthy subjects(control group)and 40.41%,49.23%,10.36% in CHD group,respectively.No significant association was noted in the distributions of genotype and the frequencies of the allele in the site between CHD and control group(P0.05).Conclusions The C(-260)T polymorphism in the promoter of CD14 gene was not associated with CHD in the Han population of Jiangsu region,and it might not be a genetic risk factor of CHD in the Han Chinese.