Association of-374T/A polymorphism of RAGE gene with coronary heart disease in Chinese Han population

Objectives To compare the differences of-374T/A polymorphism of the receptor for advanced glycation end products(RAGE) gene between patients with coronary heart disease(CHD) and non-CHD controls in the Chinese Han population,and to explore the possible association of RAGE polymorphism with CHD.Methods A case control study was performed on 215 subjects,including 127 CHD subjects and 88 non-CHD subjects.The A-T transversion polymorphism at position-374 in the promotor region of the RAGE gene was analyzed by polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP) techniques with Tsp509 I restriction enzyme.Results Differences of allele frequencies and genotype frequencies of-374T/A polymorphism between the two groups had no statistically significant(P0.05);Logistic regression analysis indicated that there was no correlation between AA genotype and CHD[OR=0.201,95% CI(0.201,4.220),P=0.9 155].Moreover,there was no association between non-diabetic CHD group and non-diabetic control group in allele frequencies and genotype frequencies as well(P0.05);Logistic regression analysis indicated that there was no correlation between AA genotype and CHD[OR=1.415,95% CI(0.253,7.926),P=0.6 929].Conclusions The RAGE-374T/A polymorphism was not associated with the susceptibility of CHD in Chinese Han population.The AA genotype may be not a protective factor for CHD in Chinese Han population.