Correlation analysis between polymorphisms of CYP11B2 (C-344T) gene and essential hypertensive risk stratification

Objective To investigate the correlation between the polymorphisms of CYP11B2(C-344T) and essential hypertensive risk stratification.Methods According to Chinese guideline for prevention and treatment of hypertension,244 cases with essential hypertension were divided into medium risk group,high risk group and very high risk group.Polymorphisms of CYP11B2(C-344T)gene were detected by PCR-restriction fragment length polymorphisms.The possible association was tested by χ2 test.Results The frequency of genotype and allele of CYP11B2(C-344T)in all groups were consistent with Hardy-Weinberg equilibrium.The frequency of CC and TT genotype in essential hypertension(EH)group was higher than that in control group,the frequency of TC genotype was lower than that in control group,but the differences were no statistically significant (P0.05).T and C allele frequency in EH group was similar with that in control group(P0.05).There was no statistically significant in the frequency of TT,TC,CC,T allele and C allele among medium risk group,high risk group,very high risk group and control group(P0.05).Conclusion The polymorphisms of CYP11B2(C-344T)gene are unrelated with essential hypertensive risk stratification.