Clinical application of glycosylated hemoglobin measurement of peripheral blood

Objective To investigate the results of glycosylated hemoglobin(HbA1c) measured with the peripheral blood and the venous whole blood,as well as the value of the detection of peripheral blood of HbA1c in the clinical application.Methods The peripheral blood and venous whole blood were taken from 311 cases of the subjects at the same time,using the PDQ PLUS HbA1c analyzer to detect the value of HbA1c of these two sets,and the results were compared by analyzed correlativity and paired t test.We used the results of peripheral blood HbA1c of 127 cases of Type 2diabetes to analyze the level of blood glucose control.The HbA1c of 15 patients with diabetes were detected by peripheral blood at different time throughout the day and the results were analyzed and valued immidiatly.Results The value of HbA1c of finger peripheral blood was significantly related to that of the venous whole blood.(r=0.988 8,P0.01,Y=0.122+0.977 X) ,but the difference was of no significance.(P=0.12) .Among the totally 127cases of Type 2diabetes,blood glucose of 35 cases were controlled very ideally(27.6%) ,41 cases were controlled well(32.3%) ,but 51 patients were not controlled ideally(40.1%) .No significant differences were noticed in the value of HbA1c of peripheral blood in the patients treated at different time throughout the day,compared with those treated with fasting(P=0.27,P=0.36,P=0.33,P=0.22,P=0.24,P=0.42) .Conclusion The value of HbA1c was determined by peripheral blood,which can be used,instead of venous whole blood,to the screening,diagnose and monitor of the patients with diabetes.