Efficacy and safety of rosuvastatin in treatment of patients with ichemic stroke for the secondary prevention of stroke

OBJECTIVE To observe the efficacy and safety of rosuvastatin in treatment of patients with ischemic stroke for the secondary prevention of stroke.METHODS 90 patients with ischemic stroke were randomized into three groups rosuvastatin,simvastatin,diet control,30 in each group.Patients in rosuvastatin group were given rosuvastatin immediately after dinner in dose of 10 mg,patients in simvastatin group were given simvastatin immediately after dinner in dose of 40 mg,patients in diet control group received diet control only.The lipid-lowering efficacy and safety were observed after 12 weeks.RESULTS The levels of TC,TG and LDL-C decreased obviously in 3 groups,but the efficiency in group rosuvastatin was more significant than in other 2 groups(P0.05).Group rosuvastatin was superior to other 2 groups in curative effect,the difference was significant(P0.05).The cholesterol reached-standard rates of group rosuvastatin was superior to other 2 groups,the difference was significant(P0.05).CONCLUSION The therapeutic effect of rosuvastatin in secondary prevention of patients with ischemic stroke is significant.Rosuvastatin is safe and worthy of clinic application.