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Efficacy and Safety of Rosuvastatin Compared to Simvaststin in Coronary Artery Disease

Shimal Khan, Amjad Abrar, Ahmad Rafique, Abdul Rehman Abid, Tehmina Jan

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Abstract

Background: Coronary artery disease is the leading cause of morbidity and mortality worldwide. Hyperlipidemia is a major risk factor for it. This trial was conducted to compare the efficacy and safety of rosuvastatin and simvastatin in patients with coronary artery disease. Material & Methods: This study was conducted at Pharamacology Department, Gomal Medical College, D.I.Khan from May 1, 2008 to December 31, 2008. Patients with history of coronary artery disease were randomized to receive Rosuvastatin 5mg or Simvastatin 20mg for six weeks. Primary end point was number of patients achieving National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) target LDL-C

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What this paper is about

Background: Coronary artery disease is the leading cause of morbidity and mortality worldwide. Hyperlipidemia is a major risk factor for it. This trial was conducted to compare the efficacy and safety of rosuvastatin and simvastatin in patients with coronary artery disease. Material & Methods: This study was conducted at Pharamacology Department, Gomal Medical College, D.I.Khan from May 1, 2008 to December 31, 2008. Patients with history of coronary artery disease were randomized to receive Rosuvastatin 5mg or Simvastatin 20mg for six weeks. Primary end point was number of patients achieving National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) target LDL-C

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Available abstract

Background: Coronary artery disease is the leading cause of morbidity and mortality worldwide. Hyperlipidemia is a major risk factor for it. This trial was conducted to compare the efficacy and safety of rosuvastatin and simvastatin in patients with coronary artery disease. Material & Methods: This study was conducted at Pharamacology Department, Gomal Medical College, D.I.Khan from May 1, 2008 to December 31, 2008. Patients with history of coronary artery disease were randomized to receive Rosuvastatin 5mg or Simvastatin 20mg for six weeks. Primary end point was number of patients achieving National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) target LDL-C

Key concepts: Rosuvastatin, Medicine, Simvastatin, Coronary artery disease, Statin, Hyperlipidemia, Internal medicine, Clinical endpoint

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