Expression of Survivin and correlation between it and prognosis of NSCLC

OBJECTIVE:To detect the expression of the Survivin,a novel inhibitor gene of apoptosis,in NSCLC,then to evaluate the clinical significance.METHODS:The expression of Survivin was determined by means of immunohistochemistry in the cancer specimens of the 50 samples.Postoperative survival was univariately analyzed by the Kaplan-Meier method,and the difference was assessed by the Log-rank test.Multivariate analyses were performed by using the COX proportional hazards modeling.RESULTS:The expression rates of Survivin in NSCLC tissues was 78.0%(39/50).Univariate analyses demonstrated that the survival rate of the 50 NSCLC patients was significantly affected by Survivin status (P=0.035) and p-TNM stages (P=0.000),and not by sex,age,tumor distribution,diameter,histology type,differenition and p-TNM staging(P0.05).Multivariate analyses (Cox proportional hazards modeling) revealed that Survivin status (P=0.027) and p-TNM stages (P=0.000) were independent prognostic factors of NSCLC patients.CONCLUSIONS:The survival rate of NSCLC patients is affected by such prognostic factors as Survivin status and p-TNM stages.Survivin status,p-TNM stagesare the two independent predictors of NSCLC patients.