Expression of ER 、PR、 Her-2 and nm23 in invasive ductal carcinoma of breast:their correlation and clinicopathological significance

Objective: To investigate the expression and significance of estrogen receptor(ER)、progestogen receptor(PR)、Her-2 and nm23 protein in breast Carcinoma.Methods:68 cases of surgical specimens from infiltrating breast Cancer were investigated by S-P immunohistochemical Staining for ER、PR、Her-2 oncogene and nm23 gene protein.Results:(1)The positive rate of ER was 55.8%,which was negatively correlated with histological grade,TNM stage and tumor size.but that did not relate to age and metastasis;(2)The positive rate of PR was 58.5%,did not relate to tumor size、histological types,age and metastasis;(3)The positive rate of Her-2 was 63.2%、The expression of Her-2 was positively correlated with histological grade,TNMstage,tumor size and lymph node metastasis,but did not realte to histological types and age;(4)The positive rate of nm23was 69.1%,which was negatively corre lated with histological grade,TNM stage and lymph node metastasis,and did not relate to tumor size and histological types;(5)The expression of ER was positively correlated with that PR,so did nm23 with ER and PR,respectively that negatively correlated with Her-2 expression.The expression of Her-2 was negatively correlated with ER expression,but did not relate to PR expression.Conclusion:The expression of ER、PR、Her-2 and nm23 in brest cancer cells reflects the pathobiologic features of the cancer.