STUDY ON THE SUBCHRONIC ORAL TOXICITY OF α-CHLOROHYDRIN ON RATS

[Objective]To study on the subchronic oral toxicity of α-chlorohydrin on rats and to obtain its NOAEL and targeted organs.[Methods]According to the subchronic oral toxicity testing method listed in the Toxicological Testing Methods for Pesticide Registration(GB15670- 1995),4 doses groups(0,15,30,75mg/kg)were set up.[Results]The body weights of male rats in high dose group(75 mg/kg)were significantly less than those of the groups(P﹤0.01),decreased values for haemoglobin concentration and erythrocyte count were found for both male and female treated rats in high dose group,the ratios of kidney weights in 30,75 mg/kg group were higher than that in the control group(P﹤0.05 or P﹤0.01),testes of male rats and kidney of both male and female rats in 30,75mg/kg group had obvious pathological damage,decreased values for sperm count and sperm motion were found for all tested male rats(P﹤0.05 or P﹤0.01).[Conclusion]The 90 days subchronic oral toxicity test shows that the exposure of 30mg/kg/d for ≥80%α-chlorohydrin has obvious damage effect on the kidney of both male and female SD rats,the exposure of 15mg/kg/d for ≥80% α-chlorohydrin has obvious effect on sperm count and sperm motion of male rats in all tested groups. Moreover,the exposure of 30mg/kg/d for ≥80% α-chlorohydrin has remarkable damage effect on reproductive system of male SD rats.