Subchronic Oral Toxicity Test of Chloramine Pyriminobac-methyl Technical Material

[Aims]The subchronic oral toxicity and maximum no observed effect level of chloramine pyriminobac-methyl technical material on rats were studied[Methods]Rats were fed by oral for 90 d at the dose of 0,62,250,1 000 mg/kg according to toxicological test methods of pesticides for registration(GB 15670—1995).[Results]The total protein(IP),albumin(ALB) and globulin(GLOB) of male rats in the high dose group increased significantly.There were significant increases in the wet weight and organ coefficient of female rats in the middle,high dose groups and male rats in the high dose group.Pathological changes of renal tubular epithelial cells such as cloudy swelling and hydropic degeneration,ect were observed in the high dose group rats.[Conclusions]The subchronic oral maximum no observed effect levels(90 d)were 77.37 mg/kg for female rats,and 73.55 mg/kg for male rats.In addition,the ADI value was recommend to be 0.073 mg/kg.