2012Zhongguo zhongyiyao xinxi zazhiRequires access

Quality Standard for Zhiweifuwei Pills

Jin Shu, Liu XiaoShuan, Xixiang Li, Jiao ZhengHua, Xiaohua Zhang

Open publisher page 1 citations

Abstract

Objective To establish a method to control the quality of Zhiweifuwei pills.Methods Mume fructus,Paeoneae radix alba,Salviae miltiorrhizae radix et rhizome and Citri reticulatae pericarpium in the preparation were identified by TLC.The content of Citrate was determined by HPLC with Symmetry C18 column as a stationary phase,acetonitrile-0.5% ammonium dihydrogen phosphate solution(5∶95) as mobile phase,and the detection wavelength was at set 212 nm.Results Qualitative identification of the characteristics of TLC spots were clear and specific.The linear correlation of Citrate was good in the range of 1.038 4-5.192 0 μg(r=0.999 5,n=5) and the recovery was 99.21%(RSD=0.86%).Conclusion This method is simple and reproducible with good specificity.It can be used for quality control of the product.

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What this paper is about

Objective To establish a method to control the quality of Zhiweifuwei pills.Methods Mume fructus,Paeoneae radix alba,Salviae miltiorrhizae radix et rhizome and Citri reticulatae pericarpium in the preparation were identified by TLC.The content of Citrate was determined by HPLC with Symmetry C18 column as a stationary phase,acetonitrile-0.5% ammonium dihydrogen phosphate solution(5∶95) as mobile phase,and the detection wavelength was at set 212 nm.Results Qualitative identification of the characteristics of TLC spots were clear and specific.The linear correlation of Citrate was good in the range of 1.038 4-5.192 0 μg(r=0.999 5,n=5) and the recovery was 99.21%(RSD=0.86%).Conclusion This method is simple and reproducible with good specificity.It can be used for quality control of the product.

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Available abstract

Objective To establish a method to control the quality of Zhiweifuwei pills.Methods Mume fructus,Paeoneae radix alba,Salviae miltiorrhizae radix et rhizome and Citri reticulatae pericarpium in the preparation were identified by TLC.The content of Citrate was determined by HPLC with Symmetry C18 column as a stationary phase,acetonitrile-0.5% ammonium dihydrogen phosphate solution(5∶95) as mobile phase,and the detection wavelength was at set 212 nm.Results Qualitative identification of the characteristics of TLC spots were clear and specific.The linear correlation of Citrate was good in the range of 1.038 4-5.192 0 μg(r=0.999 5,n=5) and the recovery was 99.21%(RSD=0.86%).Conclusion This method is simple and reproducible with good specificity.It can be used for quality control of the product.

Key concepts: Radix (gastropod), Chromatography, Quality standard, High-performance liquid chromatography, Chemistry, Linear range, Rhizome, Traditional medicine

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