Analysis of drug resistance to pathogenic bacteria of lower respiratory tract infection after upper abdominal surgery in aged patients

Objective To investigate distribution and drug resistance of pathogenic bacteria of lower respiratory tract infection after upper abdominal surgery in aged patients. Methods From 2003 to 2006,96 aged patients who underwent upper abdominal surgery and retained in the surgical intensive care unit were chosen randomly as the subjects of the present study. The distribution and drug resistance of 128 bacterial strains isolated from the sputum of these patients were analyzed by KB method. Results Of the 128 strains,102 (79.6%) were Gram negative and 26 (20.3%) Gram positive. The main bacteria causing lower respiratory tract infection included staphylococcusaureus,E. faecium,Enterobacter cioacae,Escerichiacholi,Pseudomonasaeruginosa. Most of these bacteria were sensitive to Imipenem Cilastatin,Ceftazidime,Cefoperazone Sodium,Sulbactam Sodium and Amikacin Sulfate. There was evidence that resistance to penicillin and cephalosporin antibiotics was increased. Conclusions Gram negative bacteria are main pathogenic bacteria causing lower respiratory tract infection after abdominal surgery in aged patients. Rational perioperative use of antimicrobials is able to reduce drug resistance effectively.