Incorporating 5-aminolevulinic acid-photodynamic therapy with cryotherapy in reducing the recurrence rate of condyloma acuminatum

Objective To evaluate the efficacy of combined therapy with both 5-aminolevuline acidphotodynamic therapy(ALA-PDT) and cryotherapy in the treatment of condyloma acuminatum(CA).Methods One hundred and sixty-five patients with condyloma acuminatum were randomly divided into cryotherapy group,photodynamic therapy group,and cryotherapy-photodynamic therapy group(n=55).Patients were treated by cryotherapy once 7~10 days for 2~6 times totally in cryotherapy group.In photodynamic therapy group,lesion area were coated with 20%ALA cream for 3 hours,laser irradiation were used by irradiation distance 40-80 mm,95-102 J/cm~2 for 20 minutes,every 7to 10 days,3 times totally.In cryotherapy-photodynamic therapy group,patients were treated by cryotherapy for 1 to 5 minutes and then by Photodynamic therapy.All the patients were follow-up for 3to 12 months after treatment.Results The warts were all disappeared after treatment by threemethods.The recurrence rates were 58.9%,12.5%and 5.9%while the time of recurrence were34.7,52.1 and 73.7 days in cryotherapy group,photodynamic therapy group,and cryotherapyphotodynamic therapy group respectively.Conclusion The combination therapy of ALA-PDT with cryotherapy can significantly reduce the recurrence of CA,with good tolerance.