Curative effects of home bi-level non-invasive positive airway pressure ventilation in the treatment of patients with severe chronic obstructive pulmonary disease of stable phase

Objective: To observe the curative effects of bi-level non-invasive positive airway pressure(BIPAP) ventilation in the rehabilitation treatment of patients with severe chronic obstructive pulmonary disease(COPD) of the stable phase.Methods: 42 cases of patients with severe stable phase COPD were randomly divided into 2 groups.The control group was received simple home oxygen therapy,while the treatment group was received BIPAP treatment for 2 years.During the treatment period,all selected patients were required to quit smoking,do pursed-lip breathing or abdominal breathing and other pulmonary rehabilitation exercise,and were received phlegm removing treatment if necessary.The changes of arterial blood gases,lung function,6-minute walk distance and annual hospitalization rate before treatment and 2 years after treatment were analyzed.Results: Before treatment,the arterial partial pressure of carbon dioxide(PaCO2),arterial partial pressure of oxygen(PaO2),annual hospitalization times,first second forced expiratory volume(FEV1),forced vital capacity(FVC) and 6-minute walk distance(6MWD) were compared between the treatment group and the control group,the differences were not statistically significant(t=0.886,-0.666,2.63,-0.024,0.095 and 0.635 respectively,all P0.05).Two years after treatment,the treatment group had 4 cases of death(4/21) and the control group had 6 cases of death(6/21),there was no statistically significant difference(P0 05).Two years after treatment,the PaCO2,PaO2,annual hospitalization times,FEV1,FVC and 6MWD were compared between the two groups,the differences were statistically significant(t=-16.857,5.752,-16.053,2.684,3.338 and 7.644 respectively,all P0.05).Conclusion: The BIPAP ventilation can reduce the partial pressure of PaCO2 and the annual hospitalization rate of patients with severe COPD of stable phase and has curative effects superior to the simple oxygen therapy,and thus improve the life quality of patients with stable phase COPD and achieve better long-term curative effects.