The relationship between serum resistin level and type 2 diabetes

Objective To investigate the relationship between serum resistin concentration and obese and to study the resistin correlation with insulin resistance in patients with T2DM.Methods Fasting serum resistin concentration was measured in 86 cases with T2DM and 42 subjects as controls with enzyme linked immunosorbent assay and the clinic and biochemical data of all subjects were recorded.Results The fasting serum resistin concentration was higher in obese patients than that in lean patients whether DM group or control group ( P 0.001). There was no significant difference of resistin level in serum in T2DM group and control group ( P 0.05). Relative analysis suggested that serum resistin level was positively correlated with BMI, waist, WHR, BF%, TG, ApoB, FINS, ISI, SBP, DBP and significantly negatively correlated with ISI. The stepwise multiple regression analysis shows that BF%, FINS, ISI, waist were the most influence factors on resistin (R 2 =0.78). Conclusions Serum resistin levels are higher in obese subjects than that in non obese ones. There was no significant difference of resistin level in T2DM group and control group. The study results suggested that resistin maybe play a certain role in the pathogenesis of obese, IR and T2DM.