Predictive value of cystatin C and urine protein series detection in children with Henoch-Schnlein purpura

Objective The combined detection of serum cystatin C(cystatin C) and urine protein family,of their children with Henoch-Schnlein purpura(HSP) in early diagnosis of renal damage value.Methods The main use of liquid transmission turbidity and determination of immune nephelometry CysC children HSP46 sera and urine trace protein family [transferrin(TRF),NAG/CR,IGGU/CR,ALBU/CR,α1MU/CR],simultaneous detection of urine and blood urea nitrogen(BUN),creatinine(Scr),which determine the use of NAG colorimetric endpoint method using measurement of creatinine,and compared with the healthy control group.Results HSP serum cystatin C,urine protein family detection was significantly higher than the normal control group,compared with the control group the differences were significant(P0.01);hematuria six markers in the abnormal rate was 80.43%(37/46),abnormal urine was 23.91%(11/46),the difference between them was significant;35 patients with normal urine indicators of abnormal rate of 6 74.29%(26/35),and 6 indexes abnormal rate than the two indicators increased,the differences were statistically significant;Serum cystatin C and microalbuminuria was positively related protein family.Conclusions The negative urine,and can not rule out early kidney damage,blood in urine six markers in the diagnosis of HSP is a good indicator of early renal damage,and serum cystatin C,sensitivity and specificity are superior to urine protein,so hematuria 6 items can be used as clinical markers in early diagnosis and early intervention to reduce the level of reliable evidence of renal injury.