Changes and its clinical significance of serum levels of lipoprotein(a),high sensitivity C-reactive protein in patients with acute cerebral infarction

Objective To explore the changes and its clinical significance of serum levels of lipoprotein(a) ,high sensitivity C-reactive protein(hs-CRP) in patients with acute cerebral infarction(ACI).Methods The levels of serum Lp(a) and hs-CRP in 101 ACI patients and 40 normal controls(NC group) were examined by immune-turbidimetry and immune scatter turbidimetry.ACI patients were assessed by national institutes of health stroke scale(NIHSS).The levels of serum Lp(a) and hs-CRP were compared among the patients with different NIHSS score.The relationship between levels of serum Lp(a) and hs-CRP was analyzed.Results The levels of serum Lp(a) and hs-CRP in ACI group were significant higher than those in NC group(all P0.05).The differences of serum levels of Lp(a) and hs-CRP were statistical significance among NIHSS 5,5~15 and 15 score sub-groups(all P0.05).The higher scores of NIHSS,the higher of the serum levels of Lp(a) and hs-CRP.The serum level of Lp(a) was positively related with hs-CRP(r=0.457,P0.05).Conclusions The levels of serum Lp(a) and hs-CRP are signficantly elevated in ACI patients.Lp(a) and hs-CRP may have cooperative action in ACI onset.