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2013•Chinese Journal of Modern Drug ApplicationRequires access

The dynamic change of MMP-9 after early cerebral infarction and its relationnship with the prognosis

FU Yan-hon

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Abstract

Objective To observe the dynamic change of serum MMP-9 after early cerebral infarction,and its relationnship with the prognosis.Methods 62 patients with acute cerebral infarction were selected as test group,and 28 non-symptom patients were selected as control group.Blood samples were collected of all the patients on the timespot of 24,72 h and 7 d.ALL the patients were followed up for three months and evaluated with Barthal Index.Results In early stage of acute cerebral infarction,the serum level of MMP-9 rised significantly.It was much higher at 72 h than that of the other two timespots(P0.05).The level of serum MMP-9 was paralleled with the prognosis of the disease(P0.05).Conclusion The level of serum MMP-9 in acute cerebral infarction rised obviously,and was positively correlated with the severity of disease.

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What this paper is about

Objective To observe the dynamic change of serum MMP-9 after early cerebral infarction,and its relationnship with the prognosis.Methods 62 patients with acute cerebral infarction were selected as test group,and 28 non-symptom patients were selected as control group.Blood samples were collected of all the patients on the timespot of 24,72 h and 7 d.ALL the patients were followed up for three months and evaluated with Barthal Index.Results In early stage of acute cerebral infarction,the serum level of MMP-9 rised significantly.It was much higher at 72 h than that of the other two timespots(P0.05).The level of serum MMP-9 was paralleled with the prognosis of the disease(P0.05).Conclusion The level of serum MMP-9 in acute cerebral infarction rised obviously,and was positively correlated with the severity of disease.

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Available abstract

Objective To observe the dynamic change of serum MMP-9 after early cerebral infarction,and its relationnship with the prognosis.Methods 62 patients with acute cerebral infarction were selected as test group,and 28 non-symptom patients were selected as control group.Blood samples were collected of all the patients on the timespot of 24,72 h and 7 d.ALL the patients were followed up for three months and evaluated with Barthal Index.Results In early stage of acute cerebral infarction,the serum level of MMP-9 rised significantly.It was much higher at 72 h than that of the other two timespots(P0.05).The level of serum MMP-9 was paralleled with the prognosis of the disease(P0.05).Conclusion The level of serum MMP-9 in acute cerebral infarction rised obviously,and was positively correlated with the severity of disease.

Key concepts: Medicine, Cerebral infarction, Internal medicine, Infarction, Matrix metalloproteinase, Disease, Cardiology, Gastroenterology

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