A Study on NSE and S-100β in neonates with hypoxic ischemic encephalopathy

Objective To observe the changes of neuron specific enolase(NSE)and S-100β protein in the newborn infants with hypoxic ischemic encephalopethy(HIE)and to explore its clinical significance.Methods Twenty-five infants with HIE(HIE group)and fifteen normal fullterm infants(control group)were recruited in the study.Peripheral venous blood samples on the 3rd day after birth in control group and on the 1st,3rd and 6th day after birth in HIE group were collected for detecting serum NSE by RIA and S-100β protein by ELISA.Results The levels of NSE and S-100β in HIE group on the first day after birth were higher than those in control group(P0.01).The levels of NSE and S-100β in the severe HIE group were obviously higher than those in the moderate HIE group(P0.05).The levels of NSE and S-100β were lower on the sixth day than those on the third day after birth,but still higher than those in the control group(P0.01).Conclusion NSE and S-100β may be involved in the occurrence and development of HIE.The levels of NSE and S-100β are closely correlated with the severity of HIE.