The changes and clinical significance of NSE in neonates with hypoxic ischemic encephalopathy and its correlation with naloxone treatment

Objective To observe the changes of blood neuron specific enolase(NSE) in neonates with hypoxic ischemic encephalopathy(HIE),meanwhile,to explore therapeutic effects and possible mechanism of naloxone,and provide theoretical and practical basis for the treatment of HIE. Methods The levels of NSE were examined in treatment and control groups on the 1st、4th day and 7th day after birth. Results NSE in the severe HIE group were obviously higher than those in the mild and moderate HIE group (P 0. 05). No difference was found between the mild and control groups (P 0. 05). The levels of NSE in HIE groups on the 4th day after birth were higher than those on the 1st day(P 0. 05),and lower on the 7th day after birth,but still higher than those in the control group (P 0. 05). The NSE levels of the treatment group with naloxone were reduced than that of the treatment group without naloxone significantly (P 0. 05). Conclusion NSE may be involved in the occurrence and development of HIE,and its level is closely correlated with the severity of HIE. Naloxone could stabilize nerve cell membrane,reduce NSE release and should be used within 4 days in HIE cases to exert good protection effect on neuron function.