Clinical significance of variations of IL-8 and NSE in the neweborns with hypoxic-ischemic encephalopathy

Objective To explore the changes of level of serum interleukin-8 and neuron specific enolase(NSE) in neonates with hypoxic-ischemic encephalopathy(HIE).Methods Thirty-six neonates with hypoxic ischemic encephalopathy(HIE) and twenty-one normal newborns were selected.The level of serum NSE was determined by ELISA and the level of serum IL-8 was measured with radioimmunology.Results The levels of IL-8 and NSE in HIE group were much higher than those in control group in acute stage(P0.01).The levels of IL-8 and NSE in the severe and moderate HIE groups were obviously higher than that in the slight HIE and control groups.In the recovery stage there was no obvious difference between slight HIE group and control groups.The levels of IL-8 and NSE in the severe and moderate groups were also decreased in the recovery stage,but also were higher than control and slight HIE groups(P0.01).Conclusion IL-8 and NSE may be involved in the occurrence and development of HIE,The levels of IL-8 and NSE are closely correlated with the severity and gradation of HIE.