2011•Zhonghua zhongyiyao xuekanRequires access
The Protective Effect of Xiaoyu Xiezhuo Yin on Kidney of Renal Interstitial Fibrosis Rats
Xue‐Ming Li
Open publisher page 2 citations
Abstract
Objective:To investigate the protective effect and mechanism of Xiaoyu Xiezhuo Yin on UUO rats.Methods:In the experiment,unilateral ureteric obstruction(UUO) model is adopted,32 SD rats were randomly divided into 4 groups:sham-operated group(S group),model group(M group),benazepril treated group(B group),Xiaoyu Xiezhuo Yin treated group(X group).After being intragastric administrated respectively and monitored the weight for 2 weeks,all rats were executed.Left-kidney index,levels of serum creatinine,urea nitrogen,albumin were detected;nephridial tissue were stained by HE to observe the pathologic change;immunohistochemistry was applied to measure the expression of α-SMA.Results:Xiaoyu Xiezhuo Yin decreased the level of serum creatinine,urea nitrogen and increased the the level of serum albumin obviously,and it reduced the expression of α-SMA protein in nephridial tissue,which has the significant difference compared with M group,morever,pathological changes in the X group were milder than those in the M group.Conclusion:Xiaoyu Xiezhuo Yin can effecticely delay the progression of renal fibrosis.Morever it can inhibition the expression of α-SMA and decrease the activation and formation of myofibroblasts,which is the main mechnism of anti-fibrosis.