Effects of Tang Maiping on Plasminogen Activeator Inhibior in Blood Vessel of Type 2 Diabetic Rats

Objective To investigate the effects of Chinese medicine Tang maiping(TMP)on plasminogen activeator inhibitor(PAI-1)in blood vessel endothelium of type 2 diabetic rats.Methods The models of type 2 diabetic Wistar rats were established by injecting high dosage(60 mg/kg)of streptozotocin(STZ),and fifty model rats were randomly divided into normal control group,model control group,Tang maiping group,Metformin group and Yuqanwan group.The body weight and blood sugar by cutting the rats tails were measured ever two weeks.At the sixth week rats were executed and the main arteries were sampled.The PAI-1 expression was assessed by SABC immunohistochemical method.Results For model rats,the blood sugar level rose obviously and the body weight decreased.After post-treatment,PAI-1 expression of Tang maiping group and Metformin group decreased significantly than control group(P0.01).Conclusion Tang maiping recipe can decrease the expression of PAI-1 and the incidence of microthrombus to protect the vascular structure and function in diabetic rats.