Pathological and Clinical Analysis of Tubulointerstitial Lesions in 45 Cases with Nephrotic Syndrome

Objective:To study the occurrence of tubulointerstitial lesions (TIL) in nephrotic syndrome (NS). Methods:The bio-chemical tests about renal tubular function and the pathological changes of 45 cases with nephrotic syndrome were investi-gated. Results:Compared with patients with lupus nephritis, the patients with primary glomerular nephritis (PGN) had dif-ferent urine NAG,HCO_3 ~ - ,TA,NH_4~+ and TIL (P0.05) ;proteinuria of PGN was positively correlated to urine NAG (P 0.05),urine osmolar pressure (P0.05) ,TA and NH_4~+(P0.01) and TIL (P0.01);compared with renal tubular functions of younger patients, those of older ones ( 35y) were prone to be injuried. Conclusion: Lupus nephritis causes more serious TIL than PGN;the increase of proteinuria and age may promote the development of TIL.