Relationship between poteinuria and tubulointerstitial lesions in patients with IgA nephropathy

[Objective] To investigate the relationship between proteinuria and tubulointerstitial lesions in patients with IgA nephropathy (IgAN). [Methods] According to the boundary line of 2.0 g/24 h, 33 IgAN patients diagnosed by renal biopsy were divided into an intense proteinuria group (group A) (n =13) and a no-intense proteinuria group (group B) (n =20). Prevalence characteristics of tubuloin terstitial lesions: no-TIL, mild TIL, moderate TIL and severe TIL, the clinical findings of the two groups patients with IgA nephropathy were comp- aned the relationship between TIL and Upro/24 h was found. [Results] Except for Upro/24 h among all clinical findings, there was not significant difference between the two groups patients with IgAN (P 0.05) and when the Upro/24 h was higher, the severity of TIL also increased (P 0.05). [Conclusion] Upro/24 h may be one of the key factors in the patients with IgAN, therefore, the IgAN patients with intense proteinuria should be treated positively and effectively.