Endoscopic Injection of Tissue Adhesive Combined with Esomeprazole for Upper Gastrointestinal Ulcer Bleeding

Objective To investigate the efficacy of endoscopic injection of tissue adhesive combined with esomeprazole in the treatment of upper gastrointestinal ulcer bleeding. Methods Ninetysix patients with upper gastrointestinal ulcer bleeding were divided into two groups according to the order of admission, with 48 patients in each group. The group M was given endoscopic injection of tissue adhesive combined with esomeprazole, but group N was given esomeprazole combined with norepinephrine. Hemostasis success rate on the first attempt, rebleeding rate and complications were compared between the two groups. Results Compared with group N, hemostasis success rate on the first attempt significantly increased and rebleeding rate significantly decreased in group M(100.0% vs87.5% and 2.1% vs 10.4%, respectively; P0.05). No ectopic embolism, gastrointestinal perforation and death occurred in both groups. Conclusion Endoscopic injection of tissue adhesive combined with esomeprazole is effective and simple and results in fewer complications in the treatment of upper gastrointestinal ulcer bleeding.