Clinical observation on esomeprazole in the treatment of acute upper gastrointestinal bleeding with continuous pumping administration

Objective To observe the clinical benefit rate of continuous pumping treatment of Esomeprazole on peptic ulcer with acute upper gastrointestinal bleeding. Methods In our hospital from January 2012 to March 2014, 45 patients of peptic ulcer with upper gastrointestinal hemorrhage patients were randomLy divided into observation group(n=23) and the control group(n=22). Both groups were given routine treatments as the expansion, oral norepinephrine ice brine, ecg monitoring, oxygen, indwelling gastric tube and other conventional treatment. At the same time, the observation group were firstly given a dose of 0.3 mg esomeprazole with static drop, and then a dose of 4 mg/h with 72 h continuous pumping administration; Control group were firstly given a dose of 40 mg omeprazole with static drop, and then 4mg/h with 72 h continuous pumping. Results The treatment effective rate for observation group was 91.3%, while control group 54.5%, so it was characterized when compared two groups statistically difference(x2=7.77, P0.01). In addition, there were not found obvious side effects in two groups. Conclusion The continuous pumping treatment of Esomeprazol has satisfactory effect on peptic ulcer with upper gastrointestinal bleeding, safe and reliable, worthy of clinical popularization and benefits to the peptic ulcer merge bleeding patients.