Detection of the level and its significance of VEGF, IL 6 and TNF-α in patients with type 2 diabetic nephropathy

Objective To study the detection of the level and its clinical significance of vascular endothelial growth factor(VEGF). interleukin-6(IL-6) and tumor necrosis factor-a(TNF-α) in patients with type 2 diabetic nephropathy(DN). Methods The levels of VEGF, IL-6and TNF-α in 40 patients with DN, 36 patients diagnosed simply type 2 diabetes mellitus(DM) and 38 healthy persons(healthy controls) were radioimmunologically examined. Results The level of VEGF, IL-6 and TNF-α in the DN group were markedly lower than those in the healthy group(P 0.01) and the simply type 2 DM group(P 0.01). Conclusion The VEGF, IL-6 and TNF-α were important inflammatory mediators in the development of the DN, high levels of VEGF, IL-6 and TNF-α may play important roles in the occurrence and development of the type 2 diabetes mellitus and diabetic complications, detecting the level changes can be used as references for clinical diagnosis of type 2 diabetic nephropathy.