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2010•Xiandai shengwu yixue jinzhanRequires access

Patients with diabetic nephropathy and associated cytokine levels.

Zhigang Chen, Xiaoping Yang, Jun Yang, Chunying Liu

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Abstract

Objective: To investigate TNF-α, IFN-γ, IL-6, VEGF and HGF in patients with diabeticne phrosis. Methods: Serum TNF-α, IFN-γ, IL-6, VEGF and HGF in 20 patients with diabetic nephrosis and 20 controls were measured by ELISA. Results: TNF-α, IL-6, VEGF and HGF were significantly higher in patients with diabetic nephrosis than that in controls (P0.01), but IFN-γ were significantly lower in the patients(P0.01). Conclusion: These cytokines participated in the pathogenesis of diabetic nephrosis. Monitoring the changes of their serum levels was helpful for the management of the disease.

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What this paper is about

Objective: To investigate TNF-α, IFN-γ, IL-6, VEGF and HGF in patients with diabeticne phrosis. Methods: Serum TNF-α, IFN-γ, IL-6, VEGF and HGF in 20 patients with diabetic nephrosis and 20 controls were measured by ELISA. Results: TNF-α, IL-6, VEGF and HGF were significantly higher in patients with diabetic nephrosis than that in controls (P0.01), but IFN-γ were significantly lower in the patients(P0.01). Conclusion: These cytokines participated in the pathogenesis of diabetic nephrosis. Monitoring the changes of their serum levels was helpful for the management of the disease.

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Available abstract

Objective: To investigate TNF-α, IFN-γ, IL-6, VEGF and HGF in patients with diabeticne phrosis. Methods: Serum TNF-α, IFN-γ, IL-6, VEGF and HGF in 20 patients with diabetic nephrosis and 20 controls were measured by ELISA. Results: TNF-α, IL-6, VEGF and HGF were significantly higher in patients with diabetic nephrosis than that in controls (P0.01), but IFN-γ were significantly lower in the patients(P0.01). Conclusion: These cytokines participated in the pathogenesis of diabetic nephrosis. Monitoring the changes of their serum levels was helpful for the management of the disease.

Key concepts: Nephrosis, Medicine, Pathogenesis, Diabetic nephropathy, Cytokine, Internal medicine, Tumor necrosis factor alpha, Nephropathy

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