Experimental research of piperine on glucose metabolism of model rats with insulin resistance syndrome

Aim To investigate the effect of piperine(PIP) on glucose metabolism and blood pressure(BP)of model rats with insulin resistance syndrome(IRS).Methods Rats were fed with high-fat,high-glucose and high-salt diet to establish IRS model rats. Fasting blood glucose(FBG) and BP were observed dynamically every 4 weeks. The model rats started the treatment from the 4th week and were treated for 8 weeks continuously. FBG(method of GOD-POD) and fasting insulin(FINS,method of RIA) were measured and insulin sensitivity index(ISI) was calculated,oral glucose tolerance test(OGTT) was observed,no invasion blood pressure instrument was used to measure BP.Results After 8 weeks treatment,the level of ISI in PIP group increased obviously,while the levels of FBG in serum and BP were reduced significantly,and abnormal oral glucose tolerance improved accordingly.Conclusions PIP could reduce BP and significantly improve abnormal glucose metabolism of model rats with IRS.