RELATIONSHIP BETWEEN THE SERUM URIC ACID AND INSULIN RESISTANCE IN PATIENTS WITH HYPERURICEMIA AND GOUT

Objective To clarify the relationship between serum uric acid and insulin resistance in patients with hyperuricemia and gout. Methods A control study was done in 40 hyperuricemia patients and 32 gout patients (HG group) and 32 healthy controls. Results Body mass index, systolic and diastolic blood pressure, blood glucose, total cholesterol, triglycerides apo lipoprotein(B), plasminogen, creatinine, white blood cell in the HG group were higher than those in the control group( t= 2.07- 13.01;P 0.05,0.01). Fasting serum insulin, C peptide and Homa insulin resistance(Homa IR) in the HG group increased significantly compared with those in the control. The peak value of insulin and C peptide stimulated by L arginine in the HG group was higher than that of the control ( t=2.82-7.76,P 0.01). However, the slop of insulin and C peptide secretion curve of the former decreased( t=2.82-10.95,P 0.01). Multiple step regression analysis showed that serum uric acid was positively correlated with male, triglycerides, Homa IR, creatinine, high fat intake, and alcohol drinking. Conclusion Insulin resistance is one of the factors of hyperuricemia. Measures such as decrease body weight, low fat and little alcohol intake should be taken to improve insulin resistance so to prevent hyperuricemia and gout.