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2006•Chinese Journal of Hospital PharmacyRequires access

Determination of karvedilol tablets by HPLC

Wang Likun

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Abstract

OBJECTIVE An HPLC method was established for the determination of karvedilol tablets.METHODS RP-C_(18) analytical column was used.The mobile phase consisted of methanol-0.01 mol L~(-1) phosphate buffer solution(adjust pH to(3.5) by acetic acid)(65∶35,v/v).The detection wavelength was at 245 nm.Phenobarbital sodium was used as internal seandald.RESULTS The calibration curve was linear in the range of 20-120 mg·L~(-1)of karvedilol(r=(0.999 9)).The average recovery was(100.2%),with RSD of(1.01%)(n=6).CONCLUSION The HPLC method is simple,rapid and accurate for the determination of karvedilol tablets.

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What this paper is about

OBJECTIVE An HPLC method was established for the determination of karvedilol tablets.METHODS RP-C_(18) analytical column was used.The mobile phase consisted of methanol-0.01 mol L~(-1) phosphate buffer solution(adjust pH to(3.5) by acetic acid)(65∶35,v/v).The detection wavelength was at 245 nm.Phenobarbital sodium was used as internal seandald.RESULTS The calibration curve was linear in the range of 20-120 mg·L~(-1)of karvedilol(r=(0.999 9)).The average recovery was(100.2%),with RSD of(1.01%)(n=6).CONCLUSION The HPLC method is simple,rapid and accurate for the determination of karvedilol tablets.

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Available abstract

OBJECTIVE An HPLC method was established for the determination of karvedilol tablets.METHODS RP-C_(18) analytical column was used.The mobile phase consisted of methanol-0.01 mol L~(-1) phosphate buffer solution(adjust pH to(3.5) by acetic acid)(65∶35,v/v).The detection wavelength was at 245 nm.Phenobarbital sodium was used as internal seandald.RESULTS The calibration curve was linear in the range of 20-120 mg·L~(-1)of karvedilol(r=(0.999 9)).The average recovery was(100.2%),with RSD of(1.01%)(n=6).CONCLUSION The HPLC method is simple,rapid and accurate for the determination of karvedilol tablets.

Key concepts: Chromatography, Calibration curve, High-performance liquid chromatography, Phosphate buffered saline, Chemistry, Acetic acid, Sodium, Detection limit

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