The Clinical Analysis of Primary Gastric Malignant Lymphoma

Objective To investigate the relationship between the clinical characteristics of primary gastric malignant lymphoma and Helicobacter Pylori(H.P) infection.Methods The clinical,pathological and immunohistochemical characteristics and H.P infection of 31 patients with primary gastric lymphoma were analyzed.Results The main clinical mainfestations included epigastric discomfort,abdominal mass,haematochezia and anemia.Among the 31 cases,3 cases arose from fundus of stomach,6 cases from bady of stomach,9 cases from gastric angle and 13 cases from gastric antrum.All the patients were diagnosed by histopathological and immunohistochemical studies,among which 18 were diagnosed by gastroscopy guided biopsy before operation.H.P infection was studied in all patients.29 cases exhibited B-cell phenotype and 3 patients exhibited T-cell phenotype by immunohistochemistry.H.P infection was noted in 90.2% of patients.All patients were treated by surgical resection of the primary tumor and post-operative chemotherapy.Follow-up was complete in 29 patients.The 5-year survival rate was 45.1%.Conclusion Most primary gastric malignant lymphoma are H.P infection related,B-cell lymphomas.Gastroscope guided biopsy is the useful diagnostic means before surgical resection.Postoperative chemotherapy is as important as surgical treatment.Pathological type was an important indication for evaluation of prognosis.