Nasal Toxicological Studies Bilibao Capsules

Objective: To examine the animal to give Bilibao capsules acute toxicity and long-term toxicity. Methods: The reference to Bliss method. Rats were divided into nasal capsule Bilibao high, medium and low-dose group, control group, administered orally for 4 weeks, withdrawal recovery 2 weeks. Observe the behavior of rats during the experiment activities, appearance signs, body weight, food intake changes, administration and the restoration of the end of the end of the two anatomy, routine blood testing, blood biochemistry, organ coefficient. Observe the pathological changes of tissues and organs. Results: The nasal capsule half of the lethal dose of Bilibao 128.8g/kg, 95% on average CI: 119.3~139.1g crude drug/kg; long-term toxicity experiments, Bilibao capsule of rat oral administration of high doses of nasal capsule is equivalent to Bilibao Pharmacognosy 30g/(kg·d), no obvious toxicity. Conclusion: The nasal capsule Bilibao safe and reliable.