Distribution of peripheral blood CD4~+CD25~+ regulatory T lymphocytes in patients with lung cancer and its clinical signification

Objective To evaluate the distribution of peripheral blood CD4+CD25+ regulatory T lymphocytes in patients with lung cancer and its clinical signification.Methods The peripheral blood CD4+CD25+ T cells from 45 lung cancer patients and 30 healthy volunteers was measured by flow cytometry assay,and identified by in vitro lymphocyte proliferation test.Results The percent of peripheral blood CD4+CD25+T cells in lung cancer patients was remarkably higher than that in healthy controls(P0.05),but declined after therapy(P0.05).The CD4+CD25+T cells from lung cancer patients could inhibit the proliferation of CD4+D25-T cells and secretion of IFN-γ.Conclusion Lung cancer patients showed an increased percentage of peripheral blood CD4+CD25+ regulatory T lymphocytes in patients with lung cancer,and its dynamic monitoring contributes to evaluation of immune status and therapeutic effect of lung cancer patients.