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The changes of CD4+CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cells from patients with non-small-cell lung carcinoma

Limin Liu

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Abstract

Objective: To investigate the changes of CD4 +CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cells from patients with non-small-cell lung carcinoma. Methods: Flow cytometry was used to analyze the contents of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma and patients without cancer as control. The expression of Foxp3 mRNA in peripheral blood mononuclear cells was detected by RT-PCR. Results: The population of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma was significantly higher in comparison with that of control (P0.05). The expression of Foxp3 mRNA in pa- tients with lung carcinoma was also significantly higher in comparison with that of control (P0.05). Conclusion: CD4+CD25+ regulatory T cells and its related Foxp3 may play an important role in the immune of tumor.

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What this paper is about

Objective: To investigate the changes of CD4 +CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cells from patients with non-small-cell lung carcinoma. Methods: Flow cytometry was used to analyze the contents of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma and patients without cancer as control. The expression of Foxp3 mRNA in peripheral blood mononuclear cells was detected by RT-PCR. Results: The population of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma was significantly higher in comparison with that of control (P0.05). The expression of Foxp3 mRNA in pa- tients with lung carcinoma was also significantly higher in comparison with that of control (P0.05). Conclusion: CD4+CD25+ regulatory T cells and its related Foxp3 may play an important role in the immune of tumor.

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Available abstract

Objective: To investigate the changes of CD4 +CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cells from patients with non-small-cell lung carcinoma. Methods: Flow cytometry was used to analyze the contents of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma and patients without cancer as control. The expression of Foxp3 mRNA in peripheral blood mononuclear cells was detected by RT-PCR. Results: The population of CD4+CD25+ regulatory T cells in peripheral blood from the patients with non-small-cell lung carcinoma was significantly higher in comparison with that of control (P0.05). The expression of Foxp3 mRNA in pa- tients with lung carcinoma was also significantly higher in comparison with that of control (P0.05). Conclusion: CD4+CD25+ regulatory T cells and its related Foxp3 may play an important role in the immune of tumor.

Key concepts: FOXP3, Peripheral blood mononuclear cell, Medicine, IL-2 receptor, Flow cytometry, Regulatory T cell, Immune system, Lung cancer

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The changes of CD4+CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cells from patients with non-small-cell lung carcinoma — Research Paper | ScholarLens