Changes of the expression of CD28+ and activation of various population of T cell in peripheral blood from lung cancer patients

Objective:To investigate the changes of expression of CD28 on T cells and activation of various population of T cells in peripheral blood of lung cancer patients and to study the relations of these changes with clinical stages.Methods:Three color immunofluorence staining and flow cytometry was used to detect the expression of CD28 on various population of T cells and the activation of CD28+ T cells in peripheral blood both of 38 normal persons and 42 patients with lung cancer.Results:Comparing blood of lung cancer patients were remarkably decreased(P0 05).However there was no significant difference between different clinical stages.Conclusion:The expression of CD28 and the activation of T cells was decreased in peripheral blood of lung cancer patients,which showed no obvious relations with the clinical stages.