The clinical value of serum cystatin C and urinary micro-albumin detection in the diagnosis of early renal function damage in children with henoch-schonlein purpura

Objective To explore the clinical value of serum cystatin C(Cys C) and urinary micro-albumin(m ALB) detection in the diagnosis of early renal function damage in the children with henoch-schonlein purpura(HSP). Methods 120 cases of HSP children from January 2014 to December 2014 in our hospital department of dermatology were collected. They were divided into normal renal function group(60 cases) and renal dysfunction group(60 cases) according to their renal function. In the same time, 60 healthy children were chosen as control group. The levels of serum Cys C and urine m ALB of all the children were detected and the results were analyzed statistically. Results There were statistical significance in the differences of serum Cys C and urine m ALB levels among control group, normal renal function group and renal dysfunction group(F =7.13, F= 8.54, Pall 0.05). The serum Cys C and urine m ALB levels in normal renal function group and renal dysfunction group were all higher than that of control group, and the differences all had statistical significance(Pall 0.05). The serum Cys C and urine m ALB levels in renal dysfunction group were all higher than that of normal renal function group, and the differences all had statistical significance(Pall 0.05). The positive rates of serum Cys C, urine m ALB and combine detection in HSP group were all higher than that of control group,and the differences all had statistical significance(Pall 0.05). The positive rates of serum Cys C and urine m ALB were all lower than that of combine detection, and the differences all had statistical significance(Pall0.05). Conclusion The serum Cys C and urine m ALB can be used as the index for the diagnosis of early renal function in the children with HSP.