Joint detection of urinary albumin/creatinine and cystatin C on the clinical diagnosis of early renal damage in type 2 diabetes mellitus

Objective To investigate the urinary albumin/creatinine(U-m Alb/Cr) and serum cystatin C(Cys C) value of the combined detection in diagnosis of early renal damage in type 2 diabetes mellitus. Methods The object of study selected 133 cases of type 2 diabetic patients and 45 healthy subjects,including urine protein negative and in patients with type 2 diabetes and 75 cases of group A,positive urine protein in patients with type 2 diabetes mellitus and 45 cases as group B,45 cases of healthy people were set as C group,serum urea nitrogen on three groups of subjects(BUN) and creatinine(SCr) levels were measured for comparison. Results Group A and B of U-m Alb/Cr and Cys C levels were significantly higher than those in group C(P 0.05);The U-m Alb/Cr and Cys C levels of group B were high than group A,have a significant difference(P 0.05).In group A,the positive rate of combined serum Cys C and U-m Alb/Cr detection was up to 76.0%,higher than that of the single detection. Conclusion U-m Alb/Cr is closely related to the serum Cys C level in patients with type 2 diabetes mellitus early renal damage degree,t combined serum Cys C and U-m Alb/Cr detection in early diagnosis of diabetic nephropathy,early treatment and monitoring is of great significance.