Blocking role of glucocorticoid in the course of hepatitis B to deteriorate

Objective To investigate the blocking role and safety of glucocorticoid in the course of hepatitis B to deteriorate. MethodsThe clinical data of 60 hepatitis B patients were retrospectively analyzed,their serum total bilirubin(TBIL) were higher than 68 μmol/L and lower than 171 μmol/L.All patients were divided into treatment group and control group.These two groups were administrated regular antiviral drugs.Patients in treatment group were administrated glucocorticoid individually,meanwhile,protective steps were taken in order to prevent adverse reaction.Glycyrrhizicacid was used in control group regularly. ResultsThe incidence rate of severe hepatitis in treatment group was 10.5% and lower than that in control group,it had statistical difference(P0.05).Incidence rates of adverse reaction such as hemorrhage and infection had no statistical difference between two groups(P0.05). ConclusionGlucocorticoid can improve liver function and reduce prothrombin time in hepatitis B with hyperbilirubinemia.It has an obvious therapeutic effect and little side effects such as hemorrhage and infection.But the indication should be seriously mastered,the occasion and course of treatment properly controlled and protective steps positively executed.Glycyrrhizicacid is the recommended treatment for hepatitis B with hyperbilirubinemia and it can block hepatitis B to deteriorate.