The short-term clinical effect of dexamethasone therapy in the early stage of viral hepatitis patients with heavy tendency

Objective To observe the short-term effect of dexamethasone in the early stage of acute and chronic viral hepatitis in patients with heavy tendency.Methods 65 severe acute and chronic viral hepatitis patients with heavy tendency from the year 2005 to 2010 were randomly divided into treatment group and the control group.The control group was used the conventional methods which included protecting liver,reducing jaundice and antiviral treatment,while the treatment group on the basis of conventional therapy combined with short-term dexamethasone therapy.The liver function,prothrombin activity(PTA),the total hospital days,severe hepatitis incidence rate and mortality of the two groups were compared after therapy for two weeks.The curative effect was evaluated.Results Compare to the control group,total bilirubin(TBil) decreased and Alb and PTA increased significantly in treatment group patients after therapy for two weeks.There were statistically significant differences between the two groups(P0.05),but there were no significant statistical differences between the two groups in ALT and AST(P0.05).The total hospital days of the treatment group were significantly shorter,and the severe hepatitis incidence and mortality were lower than the control group with statistical difference(P0.05).Conclusion The acute and chronic viral hepatitis patients with heavy tendency which were given short-term shock dexamethasone treatment in the early stage can improve liver function,reduce the incidence of severe hepatitis and mortality,shorten hospital stay.