The clinical significance of serum AFP,beta-HCG and uE3 screening defect for Down syndrome in mid-pregnancy

Objective To investigate the clinical significance of serum AFP,beta- HCG and u E3 screening defect for Down syndrome in mid- pregnancy. Methods Totally 1960 cases of pregnant women examined in our hospital were selected during the period from October 2009 to January 2014. The alpha- fetoprotein( AFP),human chorionic gonadotropin( beta- HCG) and free estriol( u E3) index of the pregnant women were indicated. The risk of Down's syndrome was assessed by using the risk assessment software speculate combined with maternal age,weight,gestational age and other factors. The high- risk pregnant women were given further line B- chromosomes diagnosed or amniotic fluid cells to observe the occurrence of Down syndrome births of different age groups of pregnant women. Results By the test of serum AFP,beta- HCG and u E3 of the1960 cases of mid- pregnancy women,178 cases of high- risk were tested out,the suspected positive rate is 9. 1%,including 104 cases of high risk of Down syndrome,36 cases of 18- trisomy in high- risk and 38 cases of nerve tube defects in high- risk. 24 cases of Down syndrome,8 cases of 18- trisomy syndrome and 10 cases of or amniotic fluid cells by B- chromosomes diagnosed 24 cases of neural tube defects were diagnosed by B ultrasound or amniotic fluid cells chromosomes. Pregnant women over the age of 70 are of the higher risk for Down syndrome,significantly higher than that under the age of 70,the difference was statistically significant( P 0. 05). Conclusion The serum AFP,beta- HCG and u E3 screening defect for Down syndrome in mid- pregnancy can be effectively screened positive for high- risk pregnant women. The high- risk pregnant women can have further diagnosis combined with amniotic fluid cell chromosome. This method can effectively avoide the birth of children with Down syndrome and it has played a very large supporting role for eugenics.