Analysis of serum screening results of Down's syndrome in the second trimester of pregnancy in Heyuan area

Objective To explore the risk status of pregnant women suffering from Down's syndrome in heyuan area, and evaluate the clinical value of Down's syndrome screening in mid pregnancy in prevention of birth defects. Methods The concentrations of serum AFP(AFP), Free human chorionic gonadotropin(Free-beta HCG) and Free estriol(u E3) in 5297 cases of mid pregnancy woman(14-20+6weeks) were detected by time-resolved method, and risk assessment of fetuses were done by production screen professional software combined with the gestational age, age and weight. Results Among 5297 cases of pregnant women,362 cases were at high risk of Down's syndrome, 24 cases were at high risk of neural tube defects(NTD) and 23 cases were high risk population for trisomy 18 syndrome, the positive rate of them were 6.83%, 0.45%, and 0.43% respectively. The total positive rate of pregnant women whose age were over 35 years was higher than those below 35 years(P0.05). Conclusions Mid pregnancy serological triple screening (AFP + Free- beta HCG + u E3) for fetal Down's syndrome is a non-invasive method, and screening for Down's syndrome can prevent birth defects and improve the birth population quality.