Result analysis of prenatal screening for Down syndrome in 15 549 mid-pregnancy woman in Heilongjiang

Objective To investigate the application of prenatal screening for Down syndrome( DS),trisomy 18 syndrome and neural tube defects( NTD) by detecting serum α-fetoprotein( AFP),free β-HCG( f-βHCG) and free estriol in pregnant woman( 15 ~ 20+ 6weeks).Methods Serum AFP,free β-HCG( f-βHCG) and unconjugated estriol( uE3) concentrations in pregnant woman were detected by time-resolved fluoroimmunoassay. Then the risk was evaluated by use of statistical software combined with age,gestational weeks,weight,always unusually gravid history,without diabetic,smoking history and other factors. Results Among15 549 pregnant women,782 pregnant women were found with high risk of Down syndrome,accounting for 5. 03%; 59 pregnant women were found with high risk of trisomy 18 syndrome,accounting for 0. 38%; 84 pregnant women were found with high risk of neural tube defect,accounting for 0. 54%. Nine cases,7 cases,10 cases and 6 cases were definitely diagnosed as Down syndrome,trisomy 18,other chromosome abnormalities and neural tube defect,respectively. Conclusion Prenatal screening is an effective mean of prediction severe congenita1 deformity,which can reduce the birth rate of DS and the incidence rate of invasive antenatal examination.