2007•Journal of clinical and experimental medicineRequires access
The significance of combined detection of serum CA125、CA72-4 and CA199 in diagnosis of ovarian carcinoma
Ding Xia
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Abstract
Objective To study the significance of combined detection of serum levels of CA125、CA72-4 and CA199 in diagnosis of ovarian carcinoma.Methods Serum levels of CA125、CA72-4 and CA199 in 59 patients with ovarian carcinoma, 49 patients with benign ovarian tumor and 50 healthy women for control were measured by Elctrochemilluminescent immunoassay(ECLIA).Results The serum levels of CA125、CA72-4 and CA199 in patients with ovarian carcinoma group were significantly higher than those in patients with benign ovarian tumor and normal control groups (P0.01). Their positive rates of CA125、CA72-4 and CA199 were 79.7%、61.0% and 44.8% respectively. The sensitivity of combined detection of CA125 and CA72-4 was 89.8%, and the sensitivity of combined detection of CA125 and CA199 was 81.3%. The sensitivity of combined detection of three kinds of tumor markers was 91.5%.Conclusion The significance of combined detection of serum levels of CA125、CA72-4 and CA199 is clinically important in the diagnosis of ovarian carcinoma.