Comparention of Efficacy of Reboxetine and Venlanfaxine for Post-stroke Depression Patients

OBJECTIVE:To compare the clinical efficacy and safety of reboxetine and venlanfaxine for post-stroke depression(PSD)patients.METHODS:127 PSD patients in our hospital from 2010 Apr.to 2011 Dec.were randomly divided into 2 groups.They were treated with reboxetine(n=64)and venlanfaxine(n=63)for 12 weeks.HAMD,HAMA and NIHSS were used to assess the curative effect and adverse drug reactions were recorded before treatment and 6 and 12 weeks after treatment,respectively.RESULTS:After 12 weeks of treatment,HAMD,HAMA and NIHSS of 2 groups were significantly decreased,compared with before treatment(P0.05).The total effective rate of reboxetine group was 78.1% and that of venlanfaxine group was 79.4%,there was no statistical significance(P0.05).No obvious adverse drug reactions were observed in 2 groups.CONCLUSION:In the treatment of post-stroke depression,reboxetine and venlanfaxine all have good curative effects,safety and compliance,and have light side effects.