Comparative Study of Reboxetine with Fluoxitine in the Treatmet of First-episode Depression

OBJECTIVE To study the efficacy and safety of reboxetine in the treatment of patients with first-episode depression.METHODS 54 patients with first-episode depression were randomly assigned to reboxetine groop and fluoxitine group.27 patients reseived reboxetine while 27 patients were treated with fluoxitine for 6 weeks.The efficacy was assessed with HAMD17 and HAMA and adverse reactions with TESS.RESULTS The effective rate of the reboxetine groop is 74.0%.The effective rate of the fluoxitine groop is 69.2%.There is no difference between the two groups in efficacy.While the scores of the somatization facts and HAMA of reboxetine groop significantly decreased than fluoxitine group at the end of the 4 weeks and 6 weeks.There are difference between the two groups(P0.05).The adverse reactions are low and light in two groups.CONCLUSIONS Reboxetine is a effective and safe drug in the treatment of first-episode depression patients especially with anxiety symptoms.